Multiple immune functions in rats fed echinacea extracts

This study evaluated acquired-immune functions representing the three major branches of the immune system in male rats fed a commercially available ec hinacea product. An additional comparison of effects on antibody formation in male and female rats was done using the commercial echinacea product and two echinacea tinctures marketed by local herbalists. In initial testing, we found no evidence of altered natural killer cell activity, T cell-mediat ed delayed-type hypersensitivity, or specific antibody formation in male ra ts given either a 225 mg/kg or 50 mg/kg of the commercial echinacea for 6 w eeks. Antibody formation was significantly suppressed in female but not mal e rats given 250 mg/kg for 2 weeks of the commercial echinacea. The local p roducts tested had no effect on antibody formation. We concluded that our s tudy provided no supporting evidence for immunostimulatory activity by the echinacea preparations we examined and, in fact, may be immunosuppressive u nder some conditions.