SYNTHESES AND ANTITUMOR AND ANTI-AIDS ACTIVITIES OF POLYMERS CONTAINING PYRIMIDINE DERIVATIVE

The new monomer, 5'-O-methacryloyl-3'-azido-3'-deoxythymidine (MAZT), was synthesized from methacryloyl chloride (MAC) and 3'-azido-3'-deoxy thymidine (AZT). Poly(MAZT), poly(MAZT-co-AA) and terpoly(MAZT-FUR-MAH ) were synthesized by radical polymerizations. The average molecular w eights of synthesized polymers were in the range of 8,800 similar to 2 3,000 depending on polymers. The in vivo antitumor activities of polym ers at 800mg/kg were increased in the following order : terpoly(MAZT-F UR-MAH) > poly(MAZT-co-AA) > poly(MAZT) > AZT > 5-FU. The in vitro ant i-HIV activities of synthesized polymers were less effective than thos e of AZT and D4T. But the cytotoxicities of the polymers on the MT-4 c ell line were found to be much less toxic than AZT.