Randomized trial addressing risk features and time factors of surgery plusradiotherapy in advanced head-and-neck cancer

Citation
Kk. Ang et al., Randomized trial addressing risk features and time factors of surgery plusradiotherapy in advanced head-and-neck cancer, INT J RAD O, 51(3), 2001, pp. 571-578
Citations number
19
Categorie Soggetti
Radiology ,Nuclear Medicine & Imaging","Onconogenesis & Cancer Research
Journal title
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
ISSN journal
03603016 → ACNP
Volume
51
Issue
3
Year of publication
2001
Pages
571 - 578
Database
ISI
SICI code
0360-3016(20011101)51:3<571:RTARFA>2.0.ZU;2-K
Abstract
Purpose: A multi-institutional, prospective, randomized trial was undertake n in patients with advanced head-and-neck squamous cell carcinoma to addres s (1) the validity of using pathologic risk features, established from a pr evious study, to determine the need for, and dose of, postoperative radioth erapy (PORT); (2) the impact of accelerating PORT using a concomitant boost schedule; and (3) the importance of the overall combined treatment duratio n on the treatment outcome. Methods and Materials: Of 288 consecutive patients with advanced disease re gistered preoperatively, 213 fulfilled the trial criteria and went on to re ceive therapy predicated on a set of pathologic risk features: no PORT for the low-risk group (n = 31); 57.6 Gy during 6.5 weeks for the intermediate- risk group (n = 31); and, by random assignment, 63 Gy during 5 weeks (n = 7 6) or 7 weeks (n = 75) for the high-risk group. Patients were irradiated wi th standard techniques appropriate to the site of disease and likely areas of spread. The study end points were locoregional control (LRC), survival, and morbidity. Results: Patients with low or intermediate risks had significantly higher L RC and survival rates than those with high-risk features (p = 0.003 and p = 0.0001, respectively), despite receiving no PORT or lower dose PORT, respe ctively. For high-risk patients, a trend toward higher LRC and survival rat es was noted when PORT was delivered in 5 rather than 7 weeks. A prolonged interval between surgery and PORT in the 7-week schedule was associated wit h significantly lower LRC (p = 0.03) and survival (p = 0.01) rates. Consequ ently, the cumulative duration of combined therapy had a significant impact on the LRC (p = 0.005) and survival (p = 0.03) rates. A 2-week reduction i n the PORT duration by using the concomitant boost technique did not increa se the late treatment toxicity. Conclusions: This Phase III trial established the power of risk assessment using pathologic features in determining the need for, and dose of, PORT in patients with advanced head-and-neck squamous cell cancer in a prospective , multi-institutional setting. It also revealed the impact of the overall t reatment time in the combination of surgery and PORT on the outcome in high -risk patients and showed that PORT acceleration without a reduction in dos e by a concomitant boost regimen did not increase the late complication rat e. These findings emphasize the importance of coordinated interdisciplinary care in the delivery of combined surgery and RT. (C) 2001 Elsevier Science Inc.