Application of ion-exchange resins in the separation of organic acids in biotechnological processes. Part II - Mathematical modelling of bed operation in the column
P. Gluszcz et J. Petera, Application of ion-exchange resins in the separation of organic acids in biotechnological processes. Part II - Mathematical modelling of bed operation in the column, INZ CHEM PR, 22(3B), 2001, pp. 439-444
A mathematical model of the ion-exchange process in the chromatographic col
umn is proposed in this study. The model includes mass transfer in the liqu
id phase, adsorbate diffusion in sorbent pores and phase equilibrium on the
sorbent pore surface. The model was applied to identify bed operation para
meters in the experimental column. A very good agreement between experiment
al and calculated data was obtained.