Behavioral sensitization in humans

Behavioral sensitization is the process whereby repeated, intermittent stim ulant administration produces a progressively greater and enduring behavior al response. For over two decades, behavioral sensitization has been reliab ly demonstrated in a number of different animal species and has been propos ed as a model for the development of stimulant dependence. However, the app lication of this model to humans is limited since there have been relativel y few Studies of sensitization in human subjects. Nonetheless, results from these studies suggest that, similar to animal studies, enhanced behavioral responses do occur following repeated stimulant administration that resemb le sensitization. Further research is necessary to examine characteristics of sensitization in humans, including the neurobiological systems involved. (C) 2001 by The Haworth Press, Inc, All rights reserved.