Behavioral sensitization is the process whereby repeated, intermittent stim
ulant administration produces a progressively greater and enduring behavior
al response. For over two decades, behavioral sensitization has been reliab
ly demonstrated in a number of different animal species and has been propos
ed as a model for the development of stimulant dependence. However, the app
lication of this model to humans is limited since there have been relativel
y few Studies of sensitization in human subjects. Nonetheless, results from
these studies suggest that, similar to animal studies, enhanced behavioral
responses do occur following repeated stimulant administration that resemb
le sensitization. Further research is necessary to examine characteristics
of sensitization in humans, including the neurobiological systems involved.
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