A fungal infection of the brain of a 55-year-old male patient is reported.
The lesion and involved fungus were located exclusively in the right medial
temporo-parietal region. The patient was successfully treated with surgica
l resection of the lesion and antifungal chemotherapy. Few pathogenic demat
iaceous fungi exhibit neurotropism and can cause primary infection in the c
entral nervous system (CNS). The etiological agent is described as a Noduli
sporium species. To date Nodulisporium has never been reported as an agent
of CNS infection in humans.