Four new phenylpropanoid esters of sucrose, lapathosides A (1), B (2), C (3
), and D (4), were isolated from the aerial parts of Polygonum lapathifoliu
m together with known esters, vanicoside B (5) and hydropiperoside (6). The
structures of 1-4 were determined by spectral (1D and 2D NMR and MS) analy
sis. Lapathoside A (1) and vanicoside B (2) showed significant inhibitory e
ffects on the Epstein-Barr virus early antigen activation by tumor-promoter
s.