New antifeedant bromopyrrole alkaloid from the Caribbean sponge Stylissa caribica

In this first report on the chemistry of the sponge Stylissa caribica, two known bromopyrrole metabolites and a new compound, N-methyldibromoisophakel lin (1), were isolated and identified. The structure of 1 was determined us ing spectroscopic methods and the computer program COCON. N-Methyldibromois ophakellin (1) was shown to be the only secondary metabolite in Stylissa ca ribica that, at its natural concentration, is active as a feeding deterrent against a common omnivorous reef fish.