Further analysis of prostacyclin's effect on rat gastric mucosal nucleic acid content

Authors
Balint, GA
Citation
Ga. Balint, Further analysis of prostacyclin's effect on rat gastric mucosal nucleic acid content, J PHYSL-PAR, 95(1-6), 2001, pp. 177-179
Citations number
9
Categorie Soggetti
Neurosciences & Behavoir
Journal title
JOURNAL OF PHYSIOLOGY-PARIS
ISSN journal
09284257 → ACNP
Volume
95
Issue
1-6
Year of publication
2001
Pages
177 - 179
Database
ISI
SICI code
0928-4257(200101/12)95:1-6<177:FAOPEO>2.0.ZU;2-W
Abstract
Graded single and multiple oral doses of prostacyclin enhance, in a direct dose-dependent manner, the DNA and RNA content of rat gastric (antral and f undic) mucosa, resulting in a decreased RNA/DNA ratio. This latter phenomen on is a convincing sign of new cell formation. The arithmetical (theory of functions) analysis of the data resulted in equations, defined mathematical ly, of prostacyclin's dose-dependent effect. (C) 2001 Published by Elsevier Science Ltd. All rights reserved.