On a possible new intracellular signal-system in rat gastric mucosa

Authors
Balint, GA Galfi, M Rimanoczy, A Falkay, G Juhaaz, A
Citation
Ga. Balint et al., On a possible new intracellular signal-system in rat gastric mucosa, J PHYSL-PAR, 95(1-6), 2001, pp. 243-245
Citations number
4
Categorie Soggetti
Neurosciences & Behavoir
Journal title
JOURNAL OF PHYSIOLOGY-PARIS
ISSN journal
09284257 → ACNP
Volume
95
Issue
1-6
Year of publication
2001
Pages
243 - 245
Database
ISI
SICI code
0928-4257(200101/12)95:1-6<243:OAPNIS>2.0.ZU;2-O
Abstract
It is known that cAMP and cGMP, as an "intracellular second messenger syste m" play a significant role as a signal system, in the mechanism of action o f anti-ulcerogenic (cytoprotective) drugs. According to our present. prelim inary investigations it seems that during different experimental circumstan ces the gastric mucosal 3'-5'-cyclic-cytidine-mono-phosphate (cCMP) 3'-5'-c yclic-uridine-monophosphate and (cUMP) levels were changed-similarly to CAM P and cGMP-and these changes might be a possible indicator of a further. mo st probably secondary. signal-system role. (C) 2001 Published by Elsevier S cience Ltd. All rights reserved.