Lung lesions and anti-ulcer agents beneficial effect: Anti-ulcer agents pentadecapeptide BPC 157, ranitidine, omeprazole and atropine ameliorate lunglesion in rats

Anti-ulcer agents may likely attenuate lesions outside the gastrointestinal tract. since they had protected gastrectomized rats (a "direct cytoprotect ive effect"). Therefore, their therapeutic potential in lung/stomach lesion s were shown. Rats received an intratracheal (i.t.) HCl instillation [1.5 m l/kg HCl (pH 1.75)] (lung lesion), and an intragastric (i.g.) instillation of 96% ethanol (gastric lesion, 1 ml/rat, 24 h after i.t. HCl instillation) , then sacrificed 1 h after ethanol. Basically, in lung-injured rats, the s ubsequent ethanol-gastric lesion was markedly aggravated. This aggravation, however, in turn, did not affect the severity of the lung lesions in the f urther period, at least for I h of observation. Taking intratracheal HO-ins tillation as time 0, a gastric pentadecapeptide, GEPPPGKPADDAGLV, M.W.1419, coded BPC 157 (10 mug, 10 ng, 10 pg), ranitidine (10 mg), atropine (10 mg) , omeprazole (10 mg), were given [/kg, intraperitoneally (i.p.)] (i) once, only prophylactically [as a pre-treatment (at -1h)], or as a co-treatment [ at 0)], or only therapeutically (at + 18h or + 24 h); (ii) repeatedly, comb ining prophylactic/therapeutic regimens [(-1 h) + ( + 24 h)] or [(0) + ( 24 It)], or therapeutic/therapeutic regimens [( +18 h) + ( + 24 h)]. For al l agents, combining their prophylactic and salutary regimens (at -1 h/ +24 h, or at 0/ +24 h) attenuated lung lesions; even if effect had been not see n already with a single application, it became prominent after repeated tre atment. In single application studies, relative to controls, a co-treatment (except to omeprazole), a pre-treatment (at -1 h) (pentadecapeptide BPC 15 7 and atropine, but not ranitidine and omeprazole) regularly attenuated, wh ile therapeutically, atropine (at +18 h), pentadecapeptide BPC 157 highest dose and omeprazole (at + 24 h), reversed the otherwise more severe lung le sions. (C) 2001 Elsevier Science Ltd. All rights reserved.