Cluster of metabolic syndrome factors: Pathogenetic interrelationships andapproaches to correction

Each of components of the metabolic syndrome is a well-known risk factor of atherosclerosis-related diseases, and high atherogenicity of their cluster ing seems to be due to their metabolic interrelationships. Tissue insulin r esistance is regarded as a major triggering mechanism of metabolic syndrome development. The role of other factors such as visceral adiposity, hypertr iglyceridemia and excessive free fatty acids concentration in development a nd aggravation of atherothrombosis is also important. Up to now there has b een no applicable to clinical practice adequate technique for diagnosis of early insulin resistance manifestations; that is why it seems rational to i dentify clusters of latent metabolic syndrome, including visceral adiposity , arterial hypertension and hyperlipidemias for diagnosis and prevention of development of atherosclerosis-related diseases and non-insulin-dependent diabetes. Modern approaches for nondrug and drug therapy directed on simult aneous correction of all metabolic syndrome factors clustered in one patien t are presented.