Clinical, hemodynamic and antiischemic efficacy of nebivolol in patients with mild and moderate hypertension

Clinical, hemodynamic and antiischemic efficacy of nebivolol (2.5-5-10 mg/d ay for 8 weeks) was studied in 20 patients with mild and moderate hypertens ion. Some patients also received hydrochlorothiazide (12.5 mg/day). Monothe rapy with nebivolol was effective in 55% of cases and did not cause clinica lly meaningful side effects. There were no significant changes of ECG data and such parameters of hemodynamics; as dimensions of cardiac chambers, eje ction fraction and left ventricular myocardial mass index, meanwhile total peripheral vascular resistance decreased. Therapy with nebivolol was associ ated with significant hypotensive effect, improvement of parameters of 24-h our blood pressure profile (especially of diastolic blood pressure). In 77% of cases 24-hour ECG monitoring revealed decreases in number and severity of ischemic ST-segment depressions.