Efficacy of moxonidine in patients with mild arterial hypertension in dependence on degree of stability of blood pressure elevation

Moxonidine (0,2 mg/day) was given for 4 weeks to 58 men with mild hypertens ion (stage I hypertensive disease). According to results of baseline 24-h b lood pressure monitoring the patients were divided into 2 groups - with lab ile and stable hypertensive syndrome. Clinical efficacy of moxonidine was a ssessed by repeat 24-h blood pressure monitoring and spectral analysis of 2 4-hour rhythmocardiogram. Irrespective of initial blood pressure stability treatment with moxonidine was associated with lowering of systolic and dias tolic blood pressure and both diurnal and nocturnal blood pressure burden. In patients with stable hypertensive syndrome moxonidine increased nocturna l blood pressure decline and attenuated 24-hour blood pressure variability. Contribution of parameters of 24-hour rhythmocardiogram reflecting sympath etic activity was substantially decreased during therapy with moxonidine al so especially in patients with stable hypertensive syndrome.