A study of 350 women with lichen sclerosus, originally made to elucida
te the relationship between lichen sclerosus and autoimmunity, led to
the amassing of a considerable amount of clinical material. Our review
is confined to those with anogenital lesions (342), supplemented by s
ome new cases (15), giving a total of 357 women with biopsy proven lic
hen sclerosus. It demonstrates the wide age range of the condition, th
e association with morphoea and lichen planus and the occurrence of sq
uamous cell carcinoma in some cases, It also shows that inappropriate
surgery has continued to be carried out for benign disease.