EXTRACERVICAL FIBROSCLEROSIS CAUSING OBSTRUCTION OF A VENTRICULO-PERITONEAL SHUNT IN A PATIENT WITH HYDROCEPHALUS AND INVASIVE FIBROUS THYROIDITIS (RIEDELS-STRUMA)
N. Natt et al., EXTRACERVICAL FIBROSCLEROSIS CAUSING OBSTRUCTION OF A VENTRICULO-PERITONEAL SHUNT IN A PATIENT WITH HYDROCEPHALUS AND INVASIVE FIBROUS THYROIDITIS (RIEDELS-STRUMA), Clinical endocrinology, 47(1), 1997, pp. 107-111
The association of invasive fibrous thyroiditis (IFT) with foci of ext
racervical fibrosclerosis is well recognized. Affected sites include t
he retroperitoneum, the mediastinum, the biliary tract, and the orbit.
The development of subcutaneous fibrosclerosis, however, is extremely
rare. We report a patient with known invasive fibrous thyroiditis and
hypoparathyroidism who presented with localized subcutaneous fibroscl
erosis of the anterior chest wall resulting in compression of his vent
riculoperitoneal shunt. The aetiology of IFT has remained unclear, Sev
eral histological and serological features, including the presence of
mononuclear cells within the fibrosclerotic process, the occurrence of
microscopic vasculitis, and the detection of autoantibodies directed
against thyroid-specific antigens in a large proportion of patients wi
th IFT, currently support the notion of autoimmune mechanisms playing
a role in the pathogenesis of this rare disease.