IMPROVEMENT OF ENANTIOSELECTIVE SYNTHESES AND CHIRAL HIGH-RESOLUTION GAS-CHROMATOGRAPHIC ANALYSES OF (-2-ALLYL-2-CARBOETHOXY-CYCLOPENTANOL())

Authors
FRAGA CAM BARREIRO EJ DASILVA EF DOSSANTOS AR RAMOS IDKV NETO FRD
Citation
Cam. Fraga et al., IMPROVEMENT OF ENANTIOSELECTIVE SYNTHESES AND CHIRAL HIGH-RESOLUTION GAS-CHROMATOGRAPHIC ANALYSES OF (-2-ALLYL-2-CARBOETHOXY-CYCLOPENTANOL()), Chirality, 9(4), 1997, pp. 321-324
Citations number
14
Categorie Soggetti
Chemistry Medicinal","Pharmacology & Pharmacy
Journal title
Chirality → ACNP
ISSN journal
08990042
Volume
9
Issue
4
Year of publication
1997
Pages
321 - 324
Database
ISI
SICI code
0899-0042(1997)9:4<321:IOESAC>2.0.ZU;2-6
Abstract
The improvement of the biocatalytic reduction of 2-allyl-carboethoxy-c yclopentanone (2) to the corresponding cyclopentanol derivative (+)-(1 R,2R)-(1) was accomplished employing baker's yeast in organic media. T his chiral cyclopentanol derivative (1), analyzed by high resolution g as chromatography performed over p-cyclodextrin stationary phase, was obtained in 38% yield (>99% e.e.). (C) 1997 Wiley-Liss, Inc.