ON THE ODOR OF THE ENANTIOMERS OF MADROL(R)

Authors
BUCHBAUER G LEBADA P WIESINGER L WEISSGREILER P WOLSCHANN P
Citation
G. Buchbauer et al., ON THE ODOR OF THE ENANTIOMERS OF MADROL(R), Chirality, 9(4), 1997, pp. 380-385
Citations number
16
Categorie Soggetti
Chemistry Medicinal","Pharmacology & Pharmacy
Journal title
Chirality → ACNP
ISSN journal
08990042
Volume
9
Issue
4
Year of publication
1997
Pages
380 - 385
Database
ISI
SICI code
0899-0042(1997)9:4<380:OTOOTE>2.0.ZU;2-J
Abstract
The asymmetric syntheses of the enantiomers of Madrol(R) (1) are descr ibed and their odor properties evaluated. (1S)-(-)-1 exerts a powerful sandalwood odor with some animalic undertones, whereas its antipode s mells sweet and flowery rather than like sandalwood. Molecular surface comparisons show remarkable deviations in the hydrophobic parts of th e two enantiomers. (C) 1997 Wiley-Liss, Inc.