Synthesis, antibacterial and antifungal activity of 4-substituted-5-aryl-1,2,4-triazoles

A few 4-allyl/amino-5-aryl-1,2,4-triazoles were synthesized and tested for antibacterial and antifungal effects against Escherichia coli, Bacillus sub tilis, Salmonella enteritidis, Staphylococcus aureus, Aspergillus niger and Candida albicans. 4-Allyl-5-aryl-1,2,4-triazoles were obtained by the oxid ative cyclization of the appropriate 1-substituted-4-allylthiosemicarbazide s and 4-amino-5-aryl-1,2,4-triazoles were obtained by cyclization of the po tassium salts of appropriately substituted dithiocarbazinic acids with hydr azine hydrate. The new synthesized compounds were characterized using IR, H -1-NMR, C-13-NMR and UV spectral data together with elemental analysis.