Regulation of gene expression by dopamine may play an, Important role in le
arning, reward, and addiction. Hyman and colleagues now report the characte
rization of, ania-6, a novel cyclin that associates with RNA polymerase II
and is induced by dopamine or cocaine in the neostriatum. Ania-6 may thus p
rovide a link between dopamine and gene expression at the level of mRNA pro
cessing.