Expression of RAI75 mRNA, a new member of the immunoglobulin superfamily, in developing mouse brain

RA175, a new member of the immunoglobulin superfamily, is highly expressed during neuronal differentiation of P19 embryonal carcinoma cells. In situ h ybridization showed that RA175 mRNA was detected in the developing nervous system, as well as the epithelium of the various non-neuronal tissues of mo use embryo. In contrast with the epithelia of the non-neuronal tissues, RA1 75 mRNA was not co-expressed with Sonic hedgehog mRNA and Patched mRNA duri ng brain morphogenesis. RA175 mRNA was highly expressed in the anterior hor n cells and the peripheral nervous system at embryonic day (E) 11.5 and in the central nervous system at E14.5-E18.5, but its expression decreased aft er birth and was undetectable in the adult mouse brain. NeuroReport 12:3217 -3221 (C) 2001 Lippincott Williams & Wilkins.