beta-amyloid and its binding protein in the hippocampus of diabetic mice: effect of APP17 peptide

The objective of this study was to investigate whether changes in A beta an d ERAB exist in the brain of diabetic mice, and to observe the effects of A PP17 peptide. The numbers of neurons stained by APP17 peptide A beta1-40 A beta1-42 A beta1-16 and ERAB antibodies in the brain of diabetic mice was i ncreased compared with normal mice. Staining in APP17 peptide-protected mic e was similar to normal mice. We conclude that increased A beta1-42 and ERA B is an important cause of neuronal degeneration in diabetic encephalopathy . APP17 peptide retards neuronal degeneration by regulating the metabolism of A beta. NeuroReport 12:3317-3319 (C) 2001 Lippincott Williams & Wilkins.