Involvement of NPYY2 receptor subtype in the control of the spontaneous NO/GnRH release at the rat median eminence

The role of nitric oxide (NO) from vascular endothelium in the control of G nRH release at the median eminence (ME) level is well established. Interact ions between NPY receptor/endothelium/nitric oxide are clearly demonstrated . While several studies implicate NPY Yl receptor in the control of GnRH/LH at the time of the preovulatory LH surge, our results also demonstrate the importance of NPY Y2 receptor in the control of GnRH release via endotheli al NO. We conclude that NPY may be one of the elements implicated in the ge neration of the spontaneous NO/GnRH via Y2 receptor located on endothelium. NeuroReport 12:3365-3369 (C) 2001 Lippincott Williams & Wilkins.