Synthesis of 5-methylamino-2 '-deoxyuridine derivatives

Authors
Catalanotti, B Galeone, A Mayol, L Oliviero, G Rigano, D Varra, N
Citation
B. Catalanotti et al., Synthesis of 5-methylamino-2 '-deoxyuridine derivatives, NUCLEOS NUC, 20(10-11), 2001, pp. 1831-1841
Citations number
28
Categorie Soggetti
Biochemistry & Biophysics
Journal title
NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS
ISSN journal
15257770 → ACNP
Volume
20
Issue
10-11
Year of publication
2001
Pages
1831 - 1841
Database
ISI
SICI code
1525-7770(2001)20:10-11<1831:SO5'D>2.0.ZU;2-W
Abstract
Reductive amination of 3,5'-O-(tetraisopropyldisilyloxane-1,3-diyl)2'-deoxy -5-formyluridine with several aliphatic and aromatic amines, in various sol vents, is described. In the case of aliphatic amines, the expected C-5 subs tituted methylamino pyrimidine nucleosides are formed along with by-product s deriving from opening of the pyrimidine ring. Relative amounts of the by- products depend upon the polarity of the solvent employed.