Fibroblast growth factor receptor 3 S249C mutation in virus associated squamous cell carcinomas

An S249C mutation in fibroblast growth factor receptor 3 (FGFR3) gene was r ecently identified in patients with cervical carcinomas (CC). However, its importance in cervical tumorigenesis is still inconclusive. Apart from CC, nasopharyngeal carcinoma (NPC) is the other major virus associated squamous cell carcinoma. We sought to clarify the frequency of the FGFR3 S249C muta tion in 75 primary CC in the Thai population and to determine its prevalenc e in 69 primary NPC by PCR and restriction enzyme digestion. None of the pa tients but one NPC showed the enzyme digestion pattern consistent with the mutation. This is the first report demonstrating the role of FGFR3 in the d evelopment of human NPC. This study confirms the low frequency of the FGFR3 S249C mutation in CC. Nevertheless, the discovery of the mutation, not onl y in CC as reported by previous studies, but in NPC based on this report, s uggests that FGFR3 may play a significant role in human CC and NPC developm ent.