Staphylococcus lugdunensis, a coagulase-negative staphylococcus first descr
ibed in 1988, has gained recognition as an organism with considerable patho
genic capability in adults. In contrast to the indolent presentation charac
teristic of other coagulase-negative staphylococci, S. lugdunensis infectio
ns resemble the aggressive behavior of Staphylococcus aureus. Although the
organism has been isolated from a wide variety of infections in adults, it
is a very rare cause of pediatric infections. We describe the first two ped
iatric patients who developed ventriculoperitoneal shunt infections caused
by S. lugdunensis. These cases suggest that coagulase-negative staphylococc
i should be identified to the species level and that, if S. lugdunensis is
identified, greater morbidity compared to that associated with other coagul
ase-negative staphylococcal shunt infections should be anticipated. A longe
r course of therapy is recommended for S. lugdunensis infections. Copyright
(C) 2001 S. Karger AG, Basel.