The hydroxyanilide fenhexamid, a new sterol biosynthesis inhibitor fungicide efficient against the plant pathogenic fungus Botryotinia fuckeliana (Botrytis cinerea)
D. Debieu et al., The hydroxyanilide fenhexamid, a new sterol biosynthesis inhibitor fungicide efficient against the plant pathogenic fungus Botryotinia fuckeliana (Botrytis cinerea), PEST MAN SC, 57(11), 2001, pp. 1060-1067
Fenhexamid, a recently developed botryticide, is shown here to inhibit ster
ol biosynthesis. When the fungus Botryotinia fuckeliana was grown in the pr
esence of fenhexamid, the ergosterol content was reduced, and three 3-keto
compounds, 4 alpha -methylfecosterone, fecosterone and episterone, accumula
ted, suggesting an inhibition of the 3-keto reductase involved in C-4 demet
hylation. Thus, fenhexamid belongs to a new, promising class of sterol bios
ynthesis inhibitors not previously used in agriculture or in medicine. (C)
2001 Society of Chemical Industry.