Efficacy and tolerance of Harpagophytum extract LI 174 in patients with chronic non-radicular back pain

The aim of this open, multicentre study was to evaluate the clinical effect iveness and tolerance of the Devil's Claw extract LI 174 in patients suffer ing from non-radicular back pain over a period of at least 6 months. A tota l of 130 patients were treated twice a day with tablets containing 480mg LI 174. The treatment lasted for 8 weeks. The effectiveness was judged accord ing to the Multidimensional Pain Scale (MPS), Arhus back pain index and to parameters evaluating the mobility of the lumbar spine (finger-floor distan ce, Schober's sign). Data from 117 patients were evaluated for efficacy. Th e results showed a significant improvement of pain symptoms and mobility of the affected sections of the patient's spine in the course of treatment. N o serious side effects were observed. In view of the excellent compliance a nd tolerability the investigated extract appears to be an effective plant a lternative for the treatment of chronic back pain. However, further studies will be needed to clarify the therapeutic value of this plant remedy. Copy right (C) 2001 John Wiley & Sons, Ltd.