Studies on the hypoglycaemic activity of Punica granatum seed in streptozotocin induced diabetic rats

Authors
Das, AK Mandal, SC Banerjee, SK Sinha, S Saha, BP Pal, M
Citation
Ak. Das et al., Studies on the hypoglycaemic activity of Punica granatum seed in streptozotocin induced diabetic rats, PHYTOTHER R, 15(7), 2001, pp. 628-629
Citations number
7
Categorie Soggetti
Pharmacology & Toxicology
Journal title
PHYTOTHERAPY RESEARCH
ISSN journal
0951418X → ACNP
Volume
15
Issue
7
Year of publication
2001
Pages
628 - 629
Database
ISI
SICI code
0951-418X(200111)15:7<628:SOTHAO>2.0.ZU;2-O
Abstract
The hypoglycaemic activity of Punica granatum Linn. (Family Punicaceae) see d extract on rats made diabetic by streptozotocin (STZ) was investigated. T he methanol extract of the seed at doses of 300 and 600 mg/kg, and chlorpro pamide 200 mg/kg was administered to STZ diabetic rats. The seed extract (1 50, 300 and 600 mg/kg, orally) caused a significant reduction of blood gluc ose levels in STZ induced diabetic rats by 47% and 52%, respectively, at th e end of 12 h. Copyright (C) 2001 John Wiley & Sons, Ltd.