Experimental treatment of chronic Trypanosoma cruzi infection in mice with2-N-propylquinoline

It was reported previously that 2-n-propylquinoline was active against the epimastigote form of Trypanosoma cruzi. The effects of oral treatments with benznidazole and 2-n-propylquinoline were evaluated in Balb/c mice infecte d with T. cruzi chronically. The reference drug and 2-n-propylquinoline wer e administered 60 days post-infection for 30 days at 25 mg/mL. At 35 days p ost-treatment, the serological tests (ELISA) of the 2-n-propylquinoline-tre ated mice were significantly different from the controls (p = 0.01) and the benznidazole-treated mice (p = 0.03), while this was not the case at 85 da ys post-treatment. These results are encouraging for continuing the investi gation of other analogues of 2-n-propylquinoline in experimental chronic Ch agas' disease. Copyright (C) 2001 John Wiley & Sons, Ltd.