Transesophageal and transthoracic echocardiography and Doppler-examinations in systemic lupus erythematosus

Objective: To search for cardiac abnormalities in systemic lupus erythemato sus (SLE). Methods: 35 patients examined by 2-D transthoracal Doppler and transesophag eal echocardiography. Results: Mitral and aortic valve abnormalities were seen in 12 patients (34 %) respectively, and occurred altogether in 16 patients (46%). They were in general significantly associated with longer disease duration, but not wit h anticardiolipin antibodies (aCL), disease activity, or any other variable , except for time on corticosteroids, which was significantly longer in pat ients with aortic valve calcifications. Conclusion: Valve masses and valve thickening - often in combination - are the most frequent structural findings in SLE, Occurring more often on the a ortic than on the mitral valves. Factors other than antiphospholipid antibo dies, medication, hypertension, or coronary heart disease seem to be respon sible for this phenomenon. Drugs that modulate inflammation in endo- and pe ricardial tissue may, at least in part, be responsible for the observed mit ral valve calcifications and pericardial fibrosis.