Multi-laboratory simulator studies on effects of serum proteins on PTFE cup wear

Citation
Ic. Clarke et al., Multi-laboratory simulator studies on effects of serum proteins on PTFE cup wear, WEAR, 250, 2001, pp. 188-198
Citations number
43
Categorie Soggetti
Material Science & Engineering
Journal title
WEAR
ISSN journal
00431648 → ACNP
Volume
250
Year of publication
2001
Part
1
Pages
188 - 198
Database
ISI
SICI code
0043-1648(200110)250:<188:MSSOEO>2.0.ZU;2-C
Abstract
A multi-laboratory, simulator study investigated the wear of polytetrafluor ethylene (PTFE) cups run in bovine serum. Each laboratory used its own test protocol with a variety of simulator types. Our wear model incorporated 32 mm dia CoCr heads matched to PTFE cups run with serum protein-concentratio ns in the range 17-69 mg/ml. The multi-lab data demonstrated that protein-c oncentration had the most significant effect on wear performance. Both inve rted and anatomical cups followed the same trend with first a rapid increas e in wear-rates apparent for the initially low-protein levels and then a we ar-rate reduction effect becoming apparent beyond 17 mg/ml of proteins. The results showed that as the protein concentration increased from 17 to 69 m g/ml, the magnitude of the wear-rates increased 200% but the protein wear-r ate gradient decreased 24-60% with "inverted" and "anatomical" cups, respec tively. This effect was more pronounced with "anatomical" than "inverted" c ups. Thus, the wear-trends with "inverted" cups were generally the more con sistent, particularly at the low-protein levels. Increasing the serum volum e by two-fold in one study increased the PTFE wear-magnitudes approximately 40% and the protein-wear gradient by 30%. These PTFE wear phenomena were c onsistent with the concept that low-concentrations of proteins promoted pol ymer wear but high-protein concentrations resulted in a protein-degradation phenomenon which progressively masked the actual polymer wear. In the sele cted protein range 17-69 mg/l, the multi-laboratory simulator data consiste ntly overestimated the average clinical wear-rate by at least 50-100% depen ding on protein range. It would, therefore, appear clinically relevant to s tudy PTFE wear with an inverted-cup model using a large volume of serum but only in low-protein concentrations. The protein-related wear phenomena obs erved with PTFE cups in this multi-laboratory project may also have relevan ce for wear-simulation of UHMWPE cups. (C) 2001 Elsevier Science B.V. All r ights reserved.