A comparison of simplified lansoprazole suspension administered nasogastrically and pantoprazole administered intravenously: effects on 24-h intragastric pH

Aim: To compare the 24-h intragastric pH effects of simplified lansoprazole suspension, 30 mg, administered nasogastrically, with pantoprazole, 40 mg, administered intravenously. Methods: Thirty-six healthy adults were enrolled and given simplified lanso prazole suspension, 30 mg (nasogastrically), or pantoprazole, 40 mg (intrav enously), once daily for five consecutive days in a cross-over fashion. Int ragastric pH was monitored at baseline and on Days 1 and 5 of each treatmen t period. The pharmacokinetic parameters of lansoprazole and pantoprazole w ere also determined on Days 1 and 5. Results: No statistically significant changes in pharmacokinetic parameters occurred between Days 1 and 5 with either regimen, except for pantoprazole C-max. On Days 1 and 5, significantly higher mean 24-h intragastric pH val ues were observed with 30 mg simplified lansoprazole suspension compared wi th 40 mg intravenous pantoprazole (Day 1, 3.13 vs. 2.67; Day 5, 3.95 vs. 3. 61, respectively; P<0.05). Additionally, 30 mg simplified lansoprazole susp ension produced significantly (P<0.05) higher percentages of time intragast ric pH was above 3, 4, 5 or 6 as compared with 40 mg intravenous pantoprazo le throughout Days 1 and 5. Conclusions: A 30 mg dose of simplified lansoprazole suspension administere d nasogastrically was consistently more effective at controlling intragastr ic pH than pantoprazole, 40 mg. administered intravenously.