Plasma carnitine levels in children with Down Syndrome

Carnitine is responsible for several chemical processes. including lipid me tabolism, nerve cell conduction, reduction in muscle hypotonia, and limitat ion in oxidative damage to cells. In patients with Down syndrome (DS), the process of growth is behind that of normal children and neuromuscular contr ol is attained somewhat later. The purpose of this study was to assess vari ation in levels of carnitine in normal and DS children and the relationship between the amount of carnitine and age. The study involved 30 (15 girls, 15 boys) normal children and 40 (20 girls, 20 boys) DS patients of Turkish ancestry, 6 months to 13 years of age. Carnitine level was determined using Deufel's enzymatic method. Carnitine level was significantly lower in DS p atients compared with normal children between 6 months to 5 years of age. B etween 5 and 13 years of age, the level of carnitine was about the same in both the normal and DS groups. The results suggest that carnitine level sho ws a different pattern of age related increase in DS compared to normal chi ldren. Published 2001 Wiley-Liss, Inc.