Neural correlates of traumatic memories in posttraumatic stress disorder: A functional MRI investigation

Authors
Lanius, RA Williamson, PC Densmore, M Boksman, K Gupta, MA Neufeld, RW Gati, JS Menon, RS
Citation
Ra. Lanius et al., Neural correlates of traumatic memories in posttraumatic stress disorder: A functional MRI investigation, AM J PSYCHI, 158(11), 2001, pp. 1920-1922
Citations number
10
Categorie Soggetti
Psychiatry,"Clinical Psycology & Psychiatry","Neurosciences & Behavoir
Journal title
AMERICAN JOURNAL OF PSYCHIATRY
ISSN journal
0002953X → ACNP
Volume
158
Issue
11
Year of publication
2001
Pages
1920 - 1922
Database
ISI
SICI code
0002-953X(200111)158:11<1920:NCOTMI>2.0.ZU;2-4
Abstract
Objective: The neuronal circuitry underlying posttraumatic stress disorder (PTSD) was studied in traumatized subjects with and without PTSD. Method: Traumatized subjects with (N=9) and without (N=9) PTSD were studied by using the script-driven symptom provocation paradigm adapted to functio nal magnetic resonance imaging at a 4-T field strength. Results: PTSD subjects showed significantly less activation of the thalamus , the anterior cingulate gyrus (Brodmann's area 32), and the medial frontal gyrus (Brodmann's area 10/11) than did the comparison subjects. Conclusions: The findings suggest anterior cingulate, frontal, and thalamic involvement in the neuronal circuitry underlying PTSD.