Synthesis and in vitro cytotoxicity of long chain 2-amino alcohols and 1,2-diamines

Authors
Markidis, T Padron, JM Martin, VS Peters, GJ Kokotos, G
Citation
T. Markidis et al., Synthesis and in vitro cytotoxicity of long chain 2-amino alcohols and 1,2-diamines, ANTICANC R, 21(4A), 2001, pp. 2835-2839
Citations number
21
Categorie Soggetti
Onconogenesis & Cancer Research
Journal title
ANTICANCER RESEARCH
ISSN journal
02507005 → ACNP
Volume
21
Issue
4A
Year of publication
2001
Pages
2835 - 2839
Database
ISI
SICI code
0250-7005(200107/08)21:4A<2835:SAIVCO>2.0.ZU;2-0
Abstract
The synthesis of enantiomerically pure unsaturated long chain 1,2-diamines and amino alcohols was carried out starting from the corresponding non-natu ral a-amino acids. The in vitro cytotoxicity of the compounds prepared was evaluated against six solid tumor cell lines (A2780, H322, LL, WiDr, C2610 and UMSCC-22B). Free 1,2-diamines proved to be the most active compounds ex hibiting IC50 values between 2.0 mM and 3.3 mM.