Genetic case-control association studies in neuropsychiatry

Authors
Sullivan, PF Eaves, LJ Kendler, KS Neale, MC
Citation
Pf. Sullivan et al., Genetic case-control association studies in neuropsychiatry, ARCH G PSYC, 58(11), 2001, pp. 1015-1024
Citations number
69
Categorie Soggetti
Psychiatry,"Clinical Psycology & Psychiatry","Neurosciences & Behavoir
Journal title
ARCHIVES OF GENERAL PSYCHIATRY
ISSN journal
0003990X → ACNP
Volume
58
Issue
11
Year of publication
2001
Pages
1015 - 1024
Database
ISI
SICI code
0003-990X(200111)58:11<1015:GCASIN>2.0.ZU;2-1
Abstract
Case-control association studies use genetic markers as putative etiologic risk factors. The approach is controversial and has tended to produce assoc iations in neuropsychiatry that do not stand the test of time. We studied t he processes that can bias the outcomes away from a true representation of the relationship between a genetic marker and a neuropsychiatric disorder. If conducted with care and mindfulness of the potential pitfalls, case-cont rol association studies can be an important tool for psychiatric genetic re search.