The vibrational circular dichroism (VCD) and absorption spectra of gramicid
in D in three model membranes (dioctadecyldimethylammonium chloride vesicle
s, dimyristoyl-phosphatidylcholine vesicles, and sodium dodecyl sulfate mic
elles) are presented. The absorption and VCD spectra suggest that the stabl
e gramicidin D conformation in the model membranes is different from those
in organic solvents. The presence of cations does not change the membrane-b
ound conformation of gramicidin D. (C) 2001 John Wiley & Sons, Inc.