PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR-GAMMA AND THE CONTROL OF ADIPOGENESIS

The adipose cell is now known to play a complex role in energy homeost asis, storing energy and signaling to other tissues concerning the sta te of energy balance, The past several years have seen an explosive in crease in our knowledge of the transcriptional basis of adipocyte diff erentiation. This review describes the role of peroxisome proliferator -activated receptor gamma in this process, and describes how other tra nscription factors may affect adipogenesis by modulating the amount or activity of peroxisome proliferator-activated receptor gamma, Further more, peroxisome proliferator-activated receptor gamma and other adipo genic transcription factors provide a focus for beginning to understan d how various hormones and metabolites influence the development of th is tissue in vivo.