Protein refolding in an oscillatory flow reactor

We demonstrate that an oscillatory flow reactor is a viable reactor for pro tein refolding via direct dilution. The mixing characteristics of the oscil latory flow reactor are well described and controllable and, importantly, c an be scaled-up to process scale without a loss of mixing efficiency. This makes the oscillatory flow reactor an attractive alternative to conventiona l stirred-tank reactors for process-scale renaturation.