A novel aspect of the anti-inflammatory actions of glucocorticoids: inhibition of proximal steps of signaling cascades in lymphocytes

Glucocorticoid hormones are effective in inhibiting inflammatory responses, but the mechanisms that confer this action have not been completely elucid ated. The prevailing view is that these compounds inhibit novel gene transc ription regulated by the nuclear factor kappa B and/or activator protein-1 transcription factors. In the last few years, several reports have shown th at glucocorticoids can also block signal transduction in lymphocytes at an early, postreceptor step, suggesting novel molecular targets for these horm ones. These data will be briefly reviewed and the possible in vivo relevanc e of these findings discussed, with particular emphasis on T cell developme nt.