Synthesis and anti-HIV-1 activity of new delavirdine analogues carrying arylpyrrole moieties

Authors
Pinna, GA Loriga, G Murineddu, G Grella, G Mura, M Vargiu, L Murgioni, C La Colla, P
Citation
Ga. Pinna et al., Synthesis and anti-HIV-1 activity of new delavirdine analogues carrying arylpyrrole moieties, CHEM PHARM, 49(11), 2001, pp. 1406-1411
Citations number
17
Categorie Soggetti
Chemistry & Analysis
Journal title
CHEMICAL & PHARMACEUTICAL BULLETIN
ISSN journal
00092363 → ACNP
Volume
49
Issue
11
Year of publication
2001
Pages
1406 - 1411
Database
ISI
SICI code
0009-2363(200111)49:11<1406:SAAAON>2.0.ZU;2-R
Abstract
In our search for novel anti-human immunodeficiency virus (HIV)-1 agents, 1 4 delavirdine analogues were synthesized and evaluated as potential anti-HI V-1 agents in cell-based assays. Compound 1Aa exhibited potent and selectiv e anti-HIV-1 activity in acutely infected MT4 cells, with effective concent ration (EC50) values in the submicromolar range.