Chiral HPLC separation and CD spectra of the enantiomers of the alkaloid tacamonine and related compounds

Authors
Caccamese, S Principato, G Jokela, R Tolvanen, A Belle, DD
Citation
S. Caccamese et al., Chiral HPLC separation and CD spectra of the enantiomers of the alkaloid tacamonine and related compounds, CHIRALITY, 13(10), 2001, pp. 691-693
Citations number
17
Categorie Soggetti
Chemistry & Analysis
Journal title
CHIRALITY
ISSN journal
08990042 → ACNP
Volume
13
Issue
10
Year of publication
2001
Pages
691 - 693
Database
ISI
SICI code
0899-0042(200111)13:10<691:CHSACS>2.0.ZU;2-W
Abstract
The HPLC enantiomeric separation of racemic indole alkaloids tacamonine, 17 alpha -hydroxytacamonine, deethyleburnamonine, and vindeburnol was accompl ished using Chiralpak AD and Chiralcel OD as chiral stationary phases. Smal l structural differences affect the enantioselectivity ability of these pha ses. Single enantiomers of tacamonine and vindeburnol were isolated by sein ipreparative HPLC and their CD spectra and optical rotations were measured. (C) 2001 Wiley-Liss, Inc.