Inhibition of ganciclovir-susceptible and -resistant human cytomegalovirusclinical isolates by the benzimidazole L-riboside 1263W94

Authors
McSharry, JJ McDonough, A Olson, B Talarico, C Davis, M Biron, KK
Citation
Jj. Mcsharry et al., Inhibition of ganciclovir-susceptible and -resistant human cytomegalovirusclinical isolates by the benzimidazole L-riboside 1263W94, CL DIAG LAB, 8(6), 2001, pp. 1279-1281
Citations number
23
Categorie Soggetti
Immunology
Journal title
CLINICAL AND DIAGNOSTIC LABORATORY IMMUNOLOGY
ISSN journal
1071412X → ACNP
Volume
8
Issue
6
Year of publication
2001
Pages
1279 - 1281
Database
ISI
SICI code
1071-412X(200111)8:6<1279:IOGA-H>2.0.ZU;2-M
Abstract
The average 50% inhibitory concentration (IC50) values for AD169 were 0.22 +/- 0.09 muM 1263W94 and 5.36 +/- 0.12 muM ganciclovir. For 35 human cytome galovirus (HCMV) clinical isolates the average IC50 was 0.42 +/- 0.09 muM 1 263W94, and for 26 ganciclovir-susceptible HCMV clinical isolates the avera ge IC50 was 3.78 +/- 1.62 muM ganciclovir. Nine HCMV clinical isolates: tha t were resistant to ganciclovir were completely susceptible to 1263W94.