Electronic prescribing via the Internet for a coronary artery disease and hypertension megatrial

A unique feature of the International Verapamil SR/Trandolapril Study (IN-V EST) is the Internet-based, electronic data capture system developed at the University of Florida for this trial. This system allows for direct collec tion of patient enrollment data, randomization, study drug prescribing, and real-time monitoring of patient data online. In this trial, immediate tran smission of patient-specific data occurs using online data collection forms . Investigators only need a personal computer with access to the Internet; no complicated hardware, software systems, or paper storage files are neces sary. INVEST is the first large randomized clinical trial to use electronic prescribing systems in the research setting. Electronic prescribing elimin ates errors associated with illegible handwriting, inappropriate dosing, an d inappropriate medication choice. Because the INVEST protocol allows flexi bility of medication choice and dosage range within randomly assigned treat ment strategies based on patient tolerance and blood pressure response, phy sician investigators may use individual practice patterns and preferences. The electronic system provides guidance to physicians relative to the addit ion of medication or dosage adjustments within the protocol. Electronic tra cking and reporting mechanisms have enabled investigators in this complex m egatrial to enroll, randomize, and manage patients in real time with great accuracy.