Properties of Fujicalin((R)), a new modified anhydrous dibasic calcium phosphate for direct compression: Comparison with dicalcium phosphate dihydrate

The novel, commercially available, free-flowing spherically granulated dica lcium phosphate anhydrous (SGDCPA) Fujicalin for direct tableting it,as com pared with directly compressible dicalcium phosphate dihydrate (DCPD), the properties of which are well known. The two excipients tt,ere investigated and compared with regard to their physical and powder properties, compressi bility, and compactibility. As a consequence of the spherical shape of its particles, SGDCPA shows the same good flowability and even better compactib ility. In contrast to DCPD, SGDCPA shows significant uptake of moisture whe n exposed to relative humidities (RHs) exceeding 70%. For both excipients, the main deformation mechanism is fragmentation, with SGDCPA Yielding signi ficantly stronger tablets.