CHINESE-HAMSTER OVARY CELL MUTANTS AFFECTING CHOLESTEROL-METABOLISM

The approach of somatic cell and molecular genetics for the study of i ntracellular regulation of cholesterol metabolism has blossomed in rec ent years, This review lists all the Chinese hamster ovary cell mutant s involved in cholesterol metabolism. In addition, it summarizes the c haracteristics of mutants involved in three different processes: (1) s equential cleavage of the membrane-bound sterol regulatory element-bin ding proteins; (2) cholesterol esterification; and (3) intracellular c holesterol transport from the lysosome/endosome.