We screened automated ambulatory medical records, hospital and emergency ro
om claims, and pharmacy records of 2,826 health maintenance organization (H
MO) members who gave birth over a 30-month period. Full-text ambulatory rec
ords were reviewed for the 30-day postpartum period to confirm infection st
atus for a weighted sample of cases. The overall postpartum infection rate
was 6.0%, with rates of 7.4% following cesarean section and 5.5% following
vaginal delivery. Rehospitalization; cesarean delivery; antistaphylococcal
antibiotics; diagnosis codes for mastitis, endometritis, and wound infectio
n; and ambulatory blood or wound cultures were important predictors of infe
ction. Use of automated information routinely collected by HMOs and insurer
s allows efficient identification of postpartum infections not detected by
conventional surveillance.