We studied residents of remote villages and the capital (Port Moresby) of P
apua New Guinea to determine the distribution of human herpesvirus-8 (HHV-8
) infection. Our data suggest that HHV-8 has been endemic on the island for
a long time and that the epidemiologic pattern of HHV-8 is more similar to
that of herpes simplex virus-2 than hepatitis C virus.