CONFORMATIONAL-ANALYSIS OF DDAVP AND DDAVP-OH IN METHANOL

Authors
KRAVANJA I NUTZ K ZIEGER G STERK H
Citation
I. Kravanja et al., CONFORMATIONAL-ANALYSIS OF DDAVP AND DDAVP-OH IN METHANOL, Journal of molecular structure, 328, 1994, pp. 145-151
Citations number
30
Categorie Soggetti
Chemistry Physical
Journal title
Journal of molecular structure → ACNP
ISSN journal
00222860
Volume
328
Year of publication
1994
Pages
145 - 151
Database
ISI
SICI code
0022-2860(1994)328:<145:CODADI>2.0.ZU;2-N
Abstract
The conformations of the cyclic peptides 1-desamino-8-D-arginine-vasop ressin (DDAVP) and its hydrolyzation product (DDAVP-OH) are investigat ed using C-13 and H-1 NMR spectroscopy in one and two dimensions. In m ethanolic solution both cyclic disulfides take on conformations of at least partially restricted mobility fixed by an inverse gamma-turn, wh ich is formed by a hydrogen bond between the NH proton of N5 and the C O oxygen of the F3 residue.